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Biochem Biophys Res Commun. 1987 Nov 13;148(3):1440-5.

Selective localization of vasoactive intestinal peptide and substance P in human eosinophils.

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1
Howard Hughes Medical Institute, San Francisco, California.

Abstract

Extracts of purified human eosinophils had a mean concentration of 72 fmol of immunoreactive vasoactive intestinal peptide and 21 fmol of substance P per 10(7) eosinophils, that were significantly higher than the content of immunoreactivity of the same neuropeptides in neutrophils, mononuclear leukocytes, and platelets. In contrast, the lower concentrations of calcitonin gene-related peptide and somatostatin were similar in extracts of all leukocytes. Chromatography of the peptides from eosinophils confirmed their identity with vasoactive intestinal peptide and substance P from neuroendocrine sources. Stores of some neuropeptides may endow eosinophils with unique roles in host defense and hypersensitivity reactions.

PMID:
2446611
DOI:
10.1016/s0006-291x(87)80293-0
[Indexed for MEDLINE]

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