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PLoS One. 2014 Jan 22;9(1):e85874. doi: 10.1371/journal.pone.0085874. eCollection 2014.

Dopamine signaling regulates fat content through β-oxidation in Caenorhabditis elegans.

Author information

1
Instituto Nacional de Ciência e Tecnologia de Medicina Molecular, Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
2
Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
3
Departamento de Física, Instituto de Ciências Exatas da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
4
Department of Physiology, University of California San Francisco, San Francisco, California, United States.

Abstract

The regulation of energy balance involves an intricate interplay between neural mechanisms that respond to internal and external cues of energy demand and food availability. Compelling data have implicated the neurotransmitter dopamine as an important part of body weight regulation. However, the precise mechanisms through which dopamine regulates energy homeostasis remain poorly understood. Here, we investigate mechanisms through which dopamine modulates energy storage. We showed that dopamine signaling regulates fat reservoirs in Caenorhabditis elegans. We found that the fat reducing effects of dopamine were dependent on dopaminergic receptors and a set of fat oxidation enzymes. Our findings reveal an ancient role for dopaminergic regulation of fat and suggest that dopamine signaling elicits this outcome through cascades that ultimately mobilize peripheral fat depots.

PMID:
24465759
PMCID:
PMC3899111
DOI:
10.1371/journal.pone.0085874
[Indexed for MEDLINE]
Free PMC Article
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