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PLoS One. 2014 Jan 20;9(1):e85486. doi: 10.1371/journal.pone.0085486. eCollection 2014.

Magnesium enhances exercise performance via increasing glucose availability in the blood, muscle, and brain during exercise.

Author information

1
Department of Food and Nutrition, Providence University, Shalu District, Taichung, Taiwan ; Stem Cell Center, Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
2
Stem Cell Center, Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan ; Department of Applied Chemistry, Providence University, Shalu District, Taichung, Taiwan.
3
Department of Neurosurgery, Taichung Veterans General Hospital, Taichung, Taiwan.
4
Department of Applied Cosmetology & Graduate Institute of Cosmetic Science, HungKuang University, Shalu District, Taichung, Taiwan.
5
Department of Food and Nutrition, Providence University, Shalu District, Taichung, Taiwan.

Abstract

Glucose mobilization and utilization in the periphery and central nervous system are important during exercise and are responsible for exercise efficacy. Magnesium (Mg) is involved in energy production and plays a role in exercise performance. This study aimed to explore the effects of Mg on the dynamic changes in glucose and lactate levels in the muscle, blood and brain of exercising rats using a combination of auto-blood sampling and microdialysis. Sprague-Dawley rats were pretreated with saline or magnesium sulfate (MgSO4, 90 mg/kg, i.p.) 30 min before treadmill exercise (20 m/min for 60 min). Our results indicated that the muscle, blood, and brain glucose levels immediately increased during exercise, and then gradually decreased to near basal levels in the recovery periods of both groups. These glucose levels were significantly enhanced to approximately two-fold (P<0.05) in the Mg group. Lactate levels in the muscle, blood, and brain rapidly and significantly increased in both groups during exercise, and brain lactate levels in the Mg group further elevated (P<0.05) than those in the control group during exercise. Lactate levels significantly decreased after exercise in both groups. In conclusion, Mg enhanced glucose availability in the peripheral and central systems, and increased lactate clearance in the muscle during exercise.

PMID:
24465574
PMCID:
PMC3896381
DOI:
10.1371/journal.pone.0085486
[Indexed for MEDLINE]
Free PMC Article
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