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J Gerontol A Biol Sci Med Sci. 2014 Aug;69(8):1011-7. doi: 10.1093/gerona/glt285. Epub 2014 Jan 24.

Longitudinal assessment of the menopausal transition, endogenous sex hormones, and perception of physical functioning: the Study of Women's Health Across the Nation.

Author information

1
Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pennsylvania. elkhoudarys@edc.pitt.edu.
2
Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pennsylvania.
3
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor.
4
Kaiser Permanente Division of Research, Oakland, California.
5
Center for Global Health Boonshoft School of Medicine, Wright State University, Dayton, Ohio.

Abstract

BACKGROUND:

To evaluate the longitudinal associations between menopausal status, related hormonal changes, and level of self-reported physical functioning.

METHODS:

Study included 2,495 women (age: 45-57 between 2000 and 2001) from the Study of Women's Health Across the Nation. Physical functioning scale of the Medical Outcomes Study Short-Form (SF-36; score 0-100) was categorized as: no limitation (86-100), moderate limitation (51-85), and substantial limitation (0-50). Study variables were collected between 2000 (visit-04) and 2011 (visit-12) at five timepoints. Statistical models were adjusted for age at visit-04, time since visit-04, ethnicity, site, economic status, level and change in body mass index, level and change in physical activity, and presence of comorbid conditions.

RESULTS:

In final models, natural and surgical postmenopausal women had significantly higher odds of functional limitation, compared with premenopausal women. Less reduction in estradiol and testosterone since visit-04 were significantly associated with lower odds of functional limitation, while greater increase in sex hormone-binding globulin was associated with higher odds of functional limitation.

CONCLUSIONS:

Our findings suggest the menopause-related changes in endogenous sex hormones as a possible mechanism of action to explain the greater limitation in physical functioning reported in women at midlife.

KEYWORDS:

Epidemiology; Functional performance; Geriatric endocrinology; Menopause.; Physical function

PMID:
24465026
PMCID:
PMC4158400
DOI:
10.1093/gerona/glt285
[Indexed for MEDLINE]
Free PMC Article

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