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J Atten Disord. 2017 Mar;21(5):433-441. doi: 10.1177/1087054713518239. Epub 2016 Jul 28.

Efficacy and Safety of Omega-3/6 Fatty Acids, Methylphenidate, and a Combined Treatment in Children With ADHD.

Author information

1
1 The Federico Gómez Children's Hospital of Mexico.
2
2 University Hospital Cologne, Germany.

Abstract

OBJECTIVE:

To compare efficacy of Omega-3/6 fatty acids (Equazen eye q™) with methylphenidate (MPH) and combined MPH + Omega-3/6 in children with ADHD.

METHOD:

Participants ( N = 90) were randomized to Omega-3/6, long-acting MPH, or combination for 12 months. ADHD symptoms were assessed using the ADHD Rating Scale and Clinical Global Impressions-Severity (CGI-S) scale.

RESULTS:

ADHD symptoms decreased in all treatment arms. Although significant differences favoring Omega + MPH over Omega-3/6 alone were found for ADHD Total and Hyperactivity-Impulsivity subscales, results on the Inattention subscale were similar. CGI-S scores decreased slowly and consistently with Omega-3/6, compared with a rapid decrease and subsequent slight increase in the MPH-containing arms. Adverse events were numerically less frequent with Omega-3/6 or MPH + Omega-3/6 than MPH alone.

CONCLUSION:

The tested combination of Omega-3/6 fatty acids had similar effects to MPH, whereas the MPH + Omega combination appeared to have some tolerability benefits over MPH.

KEYWORDS:

ADHD; children; methylphenidate; nonpharmacological treatment; omega fatty acids

PMID:
24464327
DOI:
10.1177/1087054713518239
[Indexed for MEDLINE]

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