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J Pediatr Gastroenterol Nutr. 2014 May;58(5):549-52. doi: 10.1097/MPG.0000000000000318.

Hydrolyzed formulas for allergy prevention.

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*UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium †Division of Neonatology, Department of Pediatrics, Georgia Regents University, Augusta ‡Schneider Children's Medical Center of Israel, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel §Department of Pediatrics, IRCCS Ospedale Maggiore Policlinico, DISCCO, University of Milan, Milan, Italy ||Department of Pediatrics, Jeanne de Flandre Lille University Children's Hospital, Faculty of Medicine, University of Lille 2, Lille, France ¶Department of Translation Medical Science, Section of Pediatrics, University of Naples "Federico II," Naples, Italy #Department of Pediatrics, Medical University of Warsaw, Warsaw, Poland.



The aim of the present review was to provide recommendations on the use of hydrolysates in infants when formula feeding is initiated.


We performed an overview of reviews followed by a systematic review of subsequently published trials.


We found 8 systematic reviews; only 1 study of limited quality was published afterwards. Certain extensively hydrolyzed casein and certain partially hydrolyzed whey formulas are appropriate for reducing the risk of allergy in infants at high risk when formula feeding is initiated.


In high-risk infants, when breast-feeding is not possible, hydrolysates of documented safety and efficacy have an indication in infant feeding up to the age 4 to 6 months.

[Indexed for MEDLINE]

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