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Nat Neurosci. 2014 Mar;17(3):423-30. doi: 10.1038/nn.3632. Epub 2014 Jan 26.

Basal ganglia subcircuits distinctively encode the parsing and concatenation of action sequences.

Author information

1
1] Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA. [2] Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California, USA.
2
Champalimaud Neuroscience Programme at Instituto Gulbenkian de Ciência and Champalimaud Center for the Unknown, Lisbon, Portugal.
3
1] Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA. [2] Champalimaud Neuroscience Programme at Instituto Gulbenkian de Ciência and Champalimaud Center for the Unknown, Lisbon, Portugal.

Abstract

Chunking allows the brain to efficiently organize memories and actions. Although basal ganglia circuits have been implicated in action chunking, little is known about how individual elements are concatenated into a behavioral sequence at the neural level. Using a task in which mice learned rapid action sequences, we uncovered neuronal activity encoding entire sequences as single actions in basal ganglia circuits. In addition to neurons with activity related to the start/stop activity signaling sequence parsing, we found neurons displaying inhibited or sustained activity throughout the execution of an entire sequence. This sustained activity covaried with the rate of execution of individual sequence elements, consistent with motor concatenation. Direct and indirect pathways of basal ganglia were concomitantly active during sequence initiation, but behaved differently during sequence performance, revealing a more complex functional organization of these circuits than previously postulated. These results have important implications for understanding the functional organization of basal ganglia during the learning and execution of action sequences.

PMID:
24464039
PMCID:
PMC3955116
DOI:
10.1038/nn.3632
[Indexed for MEDLINE]
Free PMC Article

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