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Antiviral Res. 2014 Apr;104:1-6. doi: 10.1016/j.antiviral.2014.01.008. Epub 2014 Jan 23.

Maternal antibodies by passive immunization with formalin inactivated respiratory syncytial virus confer protection without vaccine-enhanced disease.

Author information

1
Center for Inflammation, Immunity & Infection, and Department of Biology, Georgia State University, Atlanta, GA 30303, USA.
2
Animal and Plant Quarantine Agency, Anyang, Gyeonggi-do, South Korea.
3
Department of Global Medical Science, Sungshin Women's University, Seoul, South Korea.
4
Department of Pediatrics, Emory University, Atlanta, GA 30322, USA; Children's Healthcare of Atlanta, Atlanta, GA, USA.
5
Center for Inflammation, Immunity & Infection, and Department of Biology, Georgia State University, Atlanta, GA 30303, USA. Electronic address: skang24@gsu.edu.

Abstract

Maternal immunization of mice with formalin inactivated respiratory syncytial virus (FI-RSV) resulted in the passive transfer of RSV antibodies but not cellular components to the offspring. The offspring born to FI-RSV immunized mothers showed serum RSV neutralizing activity, effectively controlled lung viral loads without vaccine-enhanced disease, did not induce pulmonary eosinophilia, and cytokine producing cells after live RSV infection. Therefore, this study provides evidence that maternal immunization provides an in vivo model in investigating the roles of antibodies independent of cellular components.

KEYWORDS:

FI-RSV; Maternal antibodies; Passive immunization; Vaccine enhanced disease

PMID:
24462695
PMCID:
PMC3960005
DOI:
10.1016/j.antiviral.2014.01.008
[Indexed for MEDLINE]
Free PMC Article
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