Format

Send to

Choose Destination
See comment in PubMed Commons below
J Affect Disord. 2014 Jul;163:110-4. doi: 10.1016/j.jad.2013.12.018. Epub 2013 Dec 27.

Association analysis between suicidal behaviour and candidate genes of bipolar disorder and schizophrenia.

Author information

1
Department of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; Østmarka Psychiatric Department, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. Electronic address: per.i.finseth@ntnu.no.
2
Department of Medical Genetics, Oslo University Hospital, Oslo, Norway; K. G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
3
Department of Medical Genetics, Oslo University Hospital, Oslo, Norway; K. G. Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
4
K. G. Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.
5
Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Neuropsychiatry and Psychosomatic Medicine, Division of Surgery and Neuroscience, Oslo University Hospital, Oslo, Norway.
6
K. G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; K. G. Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
7
Department of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; Department of Research and Development, Psychiatry, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
8
Department of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; Østmarka Psychiatric Department, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.

Abstract

BACKGROUND:

The present study investigated associations between the strongest joint genetic risk variants for bipolar disorder (BD) and schizophrenia (SCZ) and a history of suicide attempt in patients with BD, SCZ and related psychiatric disorders.

METHODS:

A history of suicide attempt was assessed in a sample of 1009 patients with BD, SCZ and related psychosis spectrum disorders, and associations with the joint genetic risk variants for BD and SCZ (rs2239547 (ITIH3/4-region), rs10994359 (ANK3) and rs4765905 (CACNA1C)) were investigated. Previously reported susceptibility loci for suicide attempt in BD were also investigated. Associations were tested by logistic regression with Bonferroni correction for multiple testing.

RESULTS:

The risk allele in rs2239547 (ITIH3/4-region) was significantly associated with a history of suicide attempt (p=0.01) after multiple testing correction (p threshold<0.017). The previous suicide attempt susceptibility loci were only nominally associated, but had the same direction of risk in the replication sample (sign test, p=0.02).

LIMITATIONS:

Relatively small sample size and retrospective clinical assessment.

CONCLUSIONS:

We detected a novel association between suicide attempt and the ITIH3/4-region in a combined group of patients with BD, SCZ and related psychosis spectrum disorders. This may be useful in understanding molecular mechanisms of suicidal behaviour in severe mental disorders, although replication is warranted.

KEYWORDS:

Bipolar disorder; Candidate gene; Schizophrenia; Suicidal behaviour

PMID:
24461634
DOI:
10.1016/j.jad.2013.12.018
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center