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Asian Pac J Trop Med. 2014 Feb;7(2):113-8. doi: 10.1016/S1995-7645(14)60005-5.

Antioxidant effects of Phyllanthus niruri tea on healthy subjects.

Author information

1
Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil.
2
Laboratório de Análises Clínicas, Hospital Universitário, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil.
3
Departamento de Farmácia Industrial, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil.
4
Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil. Electronic address: jbtrocha@pq.cnpq.br.

Abstract

OBJECTIVE:

To investigate the potential antioxidant effects of Phyllanthus niruri (P. niruri, Euphorbiaceae) tea on healthy subjects.

METHODS:

Five non-smoking, male healthy volunteers, 20 to 31 years old, were enrolled. Each subject was treated twice, following a randomized crossover fashion regarding the ingestion of P. niruri infusion (5 g/750 mL) (tea group) or 750 mL of water (control group). Fasting venous blood samples were collected prior to and at 1, 2 and 4 h after infusion drinking. Samples were tested for plasmatic gallic acid and ascorbic acid levels, erythrocytic catalase and superoxide dismutase activities, and intracellular DCFH fluorescence in granulocytes, monocytes and lymphocytes.

RESULTS:

Catalase and superoxide dismutase activities were not altered by tea ingestion. Plasma levels of gallic acid were significantly increased at 1, 2 and 4 h after P. niruri ingestion and plasma ascorbic acid at 1 h after P. niruri ingestion.

CONCLUSIONS:

Ingestion of P. niruri tea is associated with a slight increase in antioxidant markers in human blood (ascorbic acid and gallic acid), which may contribute to its pharmacological effects.

KEYWORDS:

Antioxidants; Ascorbic acid; Gallic acid; Human; Phyllanthus niruri; Polyphenols

PMID:
24461523
DOI:
10.1016/S1995-7645(14)60005-5
[Indexed for MEDLINE]
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