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Chemosphere. 2014 Apr;100:71-6. doi: 10.1016/j.chemosphere.2013.12.068. Epub 2014 Jan 23.

The neurological effects of prenatal and postnatal mercury/methylmercury exposure on three-year-old children in Taiwan.

Author information

1
Graduate Institute of Environmental Engineering, National Taiwan University, Taiwan.
2
Department of Pediatrics, Taipei Mackay Memorial Hospital, Taipei, Taiwan; Mackay Junior College of Medicine, Nursing and Management, Taipei, Taiwan.
3
School of Public Health, Taipei Medical University, Taiwan.
4
School of Public Health, Taipei Medical University, Taiwan. Electronic address: lcchien@tmu.edu.tw.

Abstract

This study attempts to elucidate the relationship between neurological effects and mercury/methylmercury concentrations in various biomarkers, including meconium, hair, fingernail, and toenail. Eight-three mother-infant pairs were recruited between August 2008 and December 2009, and follow-up examinations on these children were completed after three years. The Bayley Scales of Infant and Toddler Development (Bayley-III) for evaluating the cognitive, language, and motor development of three-year-old children were calculated and validated. The geometric mean of the total mercury concentration in meconium was 89.6 ng g(-1). The methylmercury concentrations in hair, fingernail, and toenail samples were 1.96, 0.64, and 0.55 μg g(-1), respectively. Seventy percent of children had hair methylmercury concentrations exceeding the U.S. environmental protection agency (EPA) reference of 1 μg g(-1). A significantly positive correlation was obtained between methylmercury levels in hair, fingernail, and toenail. These methylmercury levels were also significantly positively correlated with the children's fish intake and negatively correlated with a Bayley-III scale score of expressive language. The prenatal mercury exposure, however, did not show significant influence on neurological development. High fish consumption appears to be a critical risk factor for methylmercury levels in children and may cause a lower expressive language score.

KEYWORDS:

Children; Fish intake; Mercury; Methylmercury; Neurological effects

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