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J Clin Periodontol. 2014 May;41(5):467-72. doi: 10.1111/jcpe.12232. Epub 2014 Feb 17.

Circulating undercarboxylated osteocalcin and gingival crevicular fluid tumour necrosis factor-α in children.

Author information

1
Faculty of Dentistry, McGill University, Montreal, QC, Canada; Epidemiology and Biostatistics Unit, INRS-Armand-Frappier Institute, Laval, QC, Canada.

Abstract

BACKGROUND:

Osteocalcin, a protein secreted by osteoblasts during bone formation, is negatively associated with adult periodontal disease. Little is known about this association in children.

AIM:

To examine the extent to which plasma undercarboxylated osteocalcin (ucOC) is associated with gingival crevicular fluid tumour necrosis factor-alpha (GCF TNF-α) - a potential marker of gingival inflammation - in children.

METHODS:

We used data from the Quebec Adipose and Lifestyle InvesTigation in Youth cohort, an ongoing longitudinal study on the natural history of obesity among Caucasian children with a family history of obesity in Quebec, Canada. This cross-sectional analysis from the baseline visit includes 120 children aged 8-10 years. Plasma ucOC and GCF TNF-α levels were determined by enzyme-linked immunosorbent assay. Linear regression analyses, adjusting for age, gender, family income, sexual maturity stage, daily physical activity, obesity, and fasting glucose were conducted, with TNF-α level as the dependent variable.

RESULTS:

A 1-ng/ml increase in ucOC was associated with a 0.96% decrease (95% confidence interval (CI): -1.69, -0.23) in GCF TNF-α level.

CONCLUSION:

A negative association between a marker of bone formation and a marker of gingival inflammation was observed as early as childhood among Caucasian children with a family history of obesity.

KEYWORDS:

bone; gingivitis; inflammation; obesity; osteocalcin; periodontal diseases; tumour necrosis factor-alpha

PMID:
24460774
DOI:
10.1111/jcpe.12232
[Indexed for MEDLINE]

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