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Biochim Biophys Acta. 2013 Mar-Apr;1819(3-4):349-55.

Chromatin-mediated Candida albicans virulence.

Author information

1
Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605-2324, USA. Jessica.LopesdaRosa@umassmed.edu
2
Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605-2324, USA.

Abstract

Candida albicans is the most prevalent human fungal pathogen. To successfully propagate an infection, this organism relies on the ability to change morphology, express virulence-associated genes and resist DNA damage caused by the host immune system. Many of these events involve chromatin alterations that are crucial for virulence. This review will focus on the studies that have been conducted on how chromatin function affects pathogenicity of C. albicans and other fungi. This article is part of a Special Issue entitled: Histone chaperones and Chromatin assembly.

PMID:
24459737
[Indexed for MEDLINE]

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