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Acta Neurol Taiwan. 2013 Dec;22(4):147-51.

Tryptophan hydroxylase 2 gene polymorphisms in Japanese patients with medication overuse headaches.

Author information

1
Department of Pharmacology, Toxicology and Therapeutics, Division of Physiology and Pathology, Showa University School of Pharmacy, Tokyo 142-8555, Japan.
2
Department of Neurology, Showa University School of Medicine, Tokyo 142-8666, Japan.

Abstract

PURPOSE:

We investigated whether tryptophan hydroxylase 2 (TPH2) gene polymorphisms were involved in the aggravation of migraines due to the overuse of medication.

METHODS:

Forty-seven migraine patients (6 males and 41 females; 36.4 10.3 years) and 22 MOH patients (1 male and 21 females; 39.6 9.9 years) who had migraines participated in this study. The genotypes for the TPH2 gene polymorphisms (rs4565946, rs4570625, and rs4341581) were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods.

RESULTS:

The rs4565946, rs4570625, and rs4341581 genotypes were similarly distributed between migraine patients and MOH patients.

CONCLUSION:

The results of this study showed no association between tryptophan TPH2 gene polymorphisms and the complication of MOH in patients with migraines.

PMID:
24458851
[Indexed for MEDLINE]
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