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J Cell Commun Signal. 2014 Jun;8(2):171-2. doi: 10.1007/s12079-014-0221-2. Epub 2014 Jan 24.

Activation of latent TGFβ by αvβ 1 integrin: of potential importance in myofibroblast activation in fibrosis.

Author information

  • 1Department of Dentistry, University of Western Ontario, Dental Sciences Building, London, ON, N6A 5C1, Canada, Andrew.Leask@schulich.uwo.ca.

Abstract

Cell-mediated activation of latent TGF-β1 is intimately involved with tissue repair and fibrosis in all organs. Previously, it was shown that the integrin β1 subunit was required for activation of latent TGF-β1 and skin fibrosis. A recent study by Henderson and colleagues (Nature Medicine 19,1617-1624, 2013) used three different in vivo models of fibrosis to show that integrin αv subunit was required for fibrogenesis. Through a process of elimination, the authors conclude that in vivo, the little-studied αvβ1 could be the major integrin responsible for TGF-β activation by myofibroblasts. Thus targeting this integrin might be a useful therapy for fibrosis.

PMID:
24458847
PMCID:
PMC4063990
DOI:
10.1007/s12079-014-0221-2
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