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RNA Biol. 2014;11(1):25-32. doi: 10.4161/rna.27717. Epub 2014 Jan 21.

Toward a crystal-clear view of the viral RNA sensing and response by RIG-I-like receptors.

Author information

1
Lee Kong Chian School of Medicine; Nanyang Technological University; Singapore.

Abstract

The RIG-I-like receptors (RLRs)--RIG-I, MDA5, and LGP2--detect intracellular pathogenic RNA and elicit an antiviral immune response during viral infection. The protein architecture of the RLR family consists of multiple functional domains, including N-terminal Caspase Activation and Recruitment Domains (CARDs) for signaling initiation, a central RNA helicase core, and a C-terminal domain for RNA sensing. With these specialized sensing-and-responding modules, RLRs are able to selectively bind non-self RNA species and trigger downstream signaling events leading to interferon production. This article summarizes the recent progress toward defining the precise mechanisms of RNA recognition and subsequent signal induction by RLRs.

KEYWORDS:

X-ray crystallography; helicase; innate immunity; signal transduction; virus infection

PMID:
24457940
PMCID:
PMC3929420
DOI:
10.4161/rna.27717
[Indexed for MEDLINE]
Free PMC Article

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