Format

Send to

Choose Destination
See comment in PubMed Commons below
Emerg Infect Dis. 2014 Feb;20(2):232-9. doi: 10.3201/eid2002.130118.

Genomic variability of monkeypox virus among humans, Democratic Republic of the Congo.

Abstract

Monkeypox virus is a zoonotic virus endemic to Central Africa. Although active disease surveillance has assessed monkeypox disease prevalence and geographic range, information about virus diversity is lacking. We therefore assessed genome diversity of viruses in 60 samples obtained from humans with primary and secondary cases of infection from 2005 through 2007. We detected 4 distinct lineages and a deletion that resulted in gene loss in 10 (16.7%) samples and that seemed to correlate with human-to-human transmission (p = 0.0544). The data suggest a high frequency of spillover events from the pool of viruses in nonhuman animals, active selection through genomic destabilization and gene loss, and increased disease transmissibility and severity. The potential for accelerated adaptation to humans should be monitored through improved surveillance.

KEYWORDS:

Democratic Republic of the Congo; Monkeypox virus; emerging infectious disease; gene loss; genomic diversity; genomic reduction; viruses

PMID:
24457084
PMCID:
PMC3901482
DOI:
10.3201/eid2002.130118
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for CDC-NCEZID Icon for PubMed Central
    Loading ...
    Support Center