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Transbound Emerg Dis. 2014 Apr;61(2):105-8. doi: 10.1111/tbed.12212. Epub 2014 Jan 24.

Middle East respiratory syndrome coronavirus antibody reactors among camels in Dubai, United Arab Emirates, in 2005.

Author information

1
National Centres for Animal Disease (NCAD), Canadian Food Inspection Agency, Canadian Science Centre for Human and Animal Health, Winnipeg, MB, Canada.

Abstract

We tested, using a low starting dilution, sequential serum samples from dromedary camels, sheep and horses collected in Dubai from February/April to October of 2005 and from dromedary camels for export/import testing between Canada and USA in 2000-2001. Using a standard Middle East respiratory syndrome coronavirus (MERS-CoV) neutralization test, serial sera from three sheep and three horses were all negative while sera from 9 of 11 dromedary camels from Dubai were positive for antibodies supported by similar results in a MERS-CoV recombinant partial spike protein antibody ELISA. The two negative Dubai camels were both dromedary calves and remained negative over the 5 months studied. The six dromedary samples from USA and Canada were negative in both tests. These results support the recent findings that infection with MERS-CoV or a closely related virus is not a new occurrence in camels in the Middle East. Therefore, interactions of MERS-CoV at the human-animal interface may have been ongoing for several, perhaps many, years and by inference, a widespread pandemic may be less likely unless significant evolution of the virus allow accelerated infection and spread potential in the human population.

KEYWORDS:

Middle East; Middle East respiratory syndrome coronavirus; antibodies; camels; coronavirus; dromedaries

PMID:
24456414
PMCID:
PMC4282458
DOI:
10.1111/tbed.12212
[Indexed for MEDLINE]
Free PMC Article
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