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J Asian Nat Prod Res. 2014;16(3):296-303. doi: 10.1080/10286020.2013.877452.

Synthesis and cytotoxic activities of a series of novel N-methyl-bisindolylmaleimide amide derivatives.

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1
a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences , Beijing , 100050 , China.

Abstract

A novel series of N-methyl-bisindolylmaleimides were synthesized and evaluated for their inhibitory activities against nine tumor cell lines. Some of the compounds showed an interesting activity against the tested cell lines. The most potent compounds 5e and 5j displayed antiproliferative activity with 50% inhibitory concentration values in the μM range against some tested cell lines.

PMID:
24456252
DOI:
10.1080/10286020.2013.877452
[Indexed for MEDLINE]
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