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Biomed Res Int. 2013;2013:761617. doi: 10.1155/2013/761617. Epub 2013 Dec 25.

Plasma miR-126 is a potential biomarker for early prediction of type 2 diabetes mellitus in susceptible individuals.

Author information

1
Department of Laboratory Medicine, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, Guangdong 518054, China.
2
Department of Control and Prevention for Chronic Non-Communicable Diseases, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, Guangdong 518054, China.
3
Biomedical Research Institute, Shenzhen PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, China.
4
Biomedical Research Institute, Shenzhen PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, China ; Shenzhen Key Laboratory for Translational Medicine of Dermatology, Shenzhen PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, China ; Shenzhen Key Discipline of Dermatology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, China ; Department of Social and Preventive Medicine, School of Public Health and Health Professions, The State University of New York, Buffalo, NY 14214, USA ; Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

Abstract

Type 2 diabetes mellitus (T2DM) is a major public health problem in China. Diagnostic markers are urgently needed to identify individuals at risk of developing T2DM and encourage them to adapt to a healthier life style. Circulating miRNAs present important sources of noninvasive biomarkers of various diseases. Recently, a novel plasma microRNA signature was identified in T2DM. Here, we evaluated the T2DM-related miRNA signature in plasma of three study groups: normal (fasting glucose (FG), 4.8-5.2 mmol/L), T2DM-susceptible (FG, 6.1-6.9 mmol/L), and T2DM individuals (FG, ≥ 7.0 mmol/L) and tested the feasibility of using circulating miRNAs to identify individuals at risk of developing T2DM. Among the 5 miRNAs included in the signature, miR-29b and miR-28-3p are not detectable. miR-15a and miR-223 have comparable expression levels among three groups. Notably, miR-126 is the only miRNA that showed significantly reduced expression in susceptible individuals and T2DM patients compared to normal individuals, suggesting that miR-126 in circulation may serve as a potential biomarker for early identification of susceptible individuals to T2DM.

PMID:
24455723
PMCID:
PMC3886569
DOI:
10.1155/2013/761617
[Indexed for MEDLINE]
Free PMC Article

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