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South Asian J Cancer. 2013 Jan;2(1):31-5. doi: 10.4103/2278-330X.105890.

Different fractionation schedules of radiotherapy in locally advanced head and neck malignancy: A prospective randomized study to compare the results of treatment and toxicities of different protocols.

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1
Department of Radiotherapy, Medical College, Kolkata, West Bengal, India.

Abstract

CONTEXT:

Altered fractionated radiotherapy may have better result than conventional radiotherapy and concomitant chemoradiotherapy to treat locally advanced head and neck cancers.

AIMS:

Evaluation of the response and toxicities in different fractionated radiotherapy schedules in locally advanced head and neck cancer.

MATERIALS AND METHODS:

Sixty four histologically proved patients of locally advanced head and neck cancer were included in the study according to protocol and were randomized into three arms. Arm A (n = 21) received 66 Gy in 33 fractions (5 fractions/week from Monday to Friday) single fraction daily in 6½ weeks along with concomitant chemotherapy (injection Cisplatin 30 mg/m(2) intravenous once weekly) for 6 weeks. Arm B (n = 21) received 66 Gy in 33 fractions (6 fractions per week) single fraction daily in 5½ weeks, and arm C (n = 22) received late hyperfractionation after 3 weeks; 30 Gy in 15 fractions in 3 weeks followed by 1.4 Gy twice daily (time gap between 2 fractions were 6 hours) for 15 days with a total of 72 Gy in 6 weeks. Response to treatment, compliance, and toxicities were compared in all the three arms.

STATISTICAL ANALYSIS USED:

Frequency table and chi square tests done.

RESULTS:

Baseline data were comparable in all the three arms. Complete response in arm A, arm B, and arm C were 15%, 26.315%, and 23.81%, respectively (P = 0.339). Grade 1 Neutropenia in arm A was 15%, arm B was 26.32%, and arm C was nil (P = 0.0486).

CONCLUSION:

Altered fractionation and concurrent chemoradiation showed similar response with comparable acute toxicities except nutropenia, which was significantly higher in arm B.

KEYWORDS:

Accelerated fractionation; concomitant chemoradiotherapy; hyperfractionation; locally advanced head and neck cancer

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