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South Asian J Cancer. 2013 Jan;2(1):4. doi: 10.4103/2278-330X.105863.

Xanthogranulomatous pyelonephritis: Rare presentation of a rare disease.

Author information

1
Department of Radiodiagnosis, Jawaharlal Nehru Medical college & Hospital, AMU, Aligarh, Uttar Pradesh, India-202002.
2
Department of Pathology, Jawaharlal Nehru Medical college & Hospital, AMU, Aligarh, Uttar Pradesh, India-202002.
3
Department of Radiotherapy, Jawaharlal Nehru Medical college & Hospital, AMU, Aligarh, Uttar Pradesh, India-202002.

Abstract

Xanthogranulomatous pyelonephritis is a rare chronic renal infection of unknown pathogenesis characterized by replacement of renal parenchyma by lipid filled macrophages frequently associated with an enlarged, non-functioning kidney and an obstructing calculus. We report a case of a 45 year old non diabetic female who presented with gradually enlarging renal mass with extensive retroperitoneal involvement and a non-functioning kidney with no evidence of obstructing stone or fat density and simulating malignancy. She was diagnosed as stage III Xanthogranulomatous pyelonephritis and managed with radical nephrectomy with favourable outcome.

KEYWORDS:

Chronic renal infection; nephrectomy; non-functioning kidney; xanthogranulomatous pyelonephritis; xanthoma cells

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