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Case Rep Hematol. 2013;2013:934781. doi: 10.1155/2013/934781. Epub 2013 Dec 17.

Malignant phyllodes tumor and acute megakaryoblastic leukemia sharing a common clonal origin.

Author information

1
Department of Hematology, University of Oslo, P.O. Box 4950, Nydalen, 0424 Oslo, Norway.
2
Department of Pathology, University of Oslo, P.O. Box 4950, Nydalen, 0424 Oslo, Norway.
3
Department of Hematology, University of Oslo, P.O. Box 4950, Nydalen, 0424 Oslo, Norway ; Institute of Clinical Medicine, University of Oslo, P.O. Box 4950, Nydalen, 0424 Oslo, Norway.
4
Department of Nuclear Medicine, Oslo University Hospital, University of Oslo, P.O. Box 4950, Nydalen, 0424 Oslo, Norway.
5
Institute of Clinical Medicine, University of Oslo, P.O. Box 4950, Nydalen, 0424 Oslo, Norway ; Section for Cancer Cytogenetics, Institute for Medical Informatics, University of Oslo, P.O. Box 4950, Nydalen, 0424 Oslo, Norway.
6
Institute of Clinical Medicine, University of Oslo, P.O. Box 4950, Nydalen, 0424 Oslo, Norway ; Department of Oncology, University of Oslo, P.O. Box 4950, Nydalen, 0424 Oslo, Norway.
7
Department of Oncology, University of Oslo, P.O. Box 4950, Nydalen, 0424 Oslo, Norway.
8
Department of Pathology, University of Oslo, P.O. Box 4950, Nydalen, 0424 Oslo, Norway ; Department of Pathology, Oslo University Hospital, Radiumhospitalet, P.O. Box 4950, Nydalen, 0424 Oslo, Norway.

Abstract

There is a well-known association in male patients between mediastinal germ cell tumors (GCT) and hematologic malignancies, with a propensity towards acute megakaryoblastic leukemia. These rare malignancies have been shown to share a common clonal origin, often deduced from the finding of isochromosome 12p, i(12p), in cells from both the solid tumor and the leukemia, and thus are now known to represent different manifestations of the same clonal process. We treated a young female patient with a malignant phyllodes tumor followed by an acute megakaryoblastic leukemia and found several of the same marker chromosomes by karyotype analysis of cells from both the tumor and the leukemia implying a common clonal origin of the two. To the best of our knowledge, this has not been demonstrated in phyllodes tumors before, but indicates that the same type of leukemization may occur of this tumor as has been described in mediastinal GCT.

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