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PLoS One. 2014 Jan 15;9(1):e83993. doi: 10.1371/journal.pone.0083993. eCollection 2014.

Oxytocin receptor gene polymorphisms are associated with human directed social behavior in dogs (Canis familiaris).

Author information

1
Department of Ethology, Eötvös Loránd University, Budapest, Hungary ; Research Centre for Natural Sciences, Institute of Cognitive Neuroscience and Psychology, Hungarian Academy of Sciences, Budapest, Hungary.
2
Comparative Ethology Research Group, MTA-ELTE, Budapest, Hungary.
3
Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary.
4
Department of Ethology and Animal Welfare, Catholic University College Ghent, Brugge, Belgium.
5
Department of Animal and Aquacultural Sciences, Norwegian University of Life Sciences, Ås, Norway.
6
Department of Ethology, Eötvös Loránd University, Budapest, Hungary.
7
Department of Ethology, Eötvös Loránd University, Budapest, Hungary ; Comparative Ethology Research Group, MTA-ELTE, Budapest, Hungary.

Abstract

The oxytocin system has a crucial role in human sociality; several results prove that polymorphisms of the oxytocin receptor gene are related to complex social behaviors in humans. Dogs' parallel evolution with humans and their adaptation to the human environment has made them a useful species to model human social interactions. Previous research indicates that dogs are eligible models for behavioral genetic research, as well. Based on these previous findings, our research investigated associations between human directed social behaviors and two newly described (-212AG, 19131AG) and one known (rs8679684) single nucleotide polymorphisms (SNPs) in the regulatory regions (5' and 3' UTR) of the oxytocin receptor gene in German Shepherd (N = 104) and Border Collie (N = 103) dogs. Dogs' behavior traits have been estimated in a newly developed test series consisting of five episodes: Greeting by a stranger, Separation from the owner, Problem solving, Threatening approach, Hiding of the owner. Buccal samples were collected and DNA was isolated using standard protocols. SNPs in the 3' and 5' UTR regions were analyzed by polymerase chain reaction based techniques followed by subsequent electrophoresis analysis. The gene-behavior association analysis suggests that oxytocin receptor gene polymorphisms have an impact in both breeds on (i) proximity seeking towards an unfamiliar person, as well as their owner, and on (ii) how friendly dogs behave towards strangers, although the mediating molecular regulatory mechanisms are yet unknown. Based on these results, we conclude that similarly to humans, the social behavior of dogs towards humans is influenced by the oxytocin system.

PMID:
24454713
PMCID:
PMC3893090
DOI:
10.1371/journal.pone.0083993
[Indexed for MEDLINE]
Free PMC Article

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