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J Renin Angiotensin Aldosterone Syst. 2015 Dec;16(4):838-43. doi: 10.1177/1470320313516172. Epub 2014 Jan 22.

Association of ACE and MTHFR genetic polymorphisms with type 2 diabetes mellitus: Susceptibility and complications.

Author information

1
Genetics Unit, Mansoura University, Egypt settin@mans.edu.eg.
2
Genetics Unit, Mansoura University, Egypt.
3
Zoology Department, Mansoura University, Egypt.

Abstract

HYPOTHESIS/INTRODUCTION:

Polymorphisms of angiotensin converting enzyme (ACE) and methylene-tetrahydrofolate reductase (MTHFR) genes have been proposed to be associated with type 2 diabetes mellitus (T2DM) with conflicting results. This work was planned in order to check for the association of these polymorphisms with the susceptibility for and complications of T2DM among Egyptian cases.

MATERIALS AND METHODS:

This is a case controlled study involving 203 patients with T2DM and 311 healthy controls. Polymorphic variants of ACE I>D and MTHFR (677 C>T and 1298 A>C) were determined using the polymerase chain reaction (PCR) restriction analysis technique.

RESULTS:

The susceptibility to T2DM was higher among subjects having the MTHFR 677TT (odds ratio (OR)=2.2, p=0.01), MTHFR 1298 AA (OR=1.84, p=0.001) and ACE (ID+II) (OR=2.0, p=0.0007) genotypes. Logistic regression analysis showed that MTHFR 677T allele was a risk factor for diabetic retinopathy (DR) (OR=3.47, p<0.001), diabetic polyneuropathy (DPN) (OR=5.2, p<0.0001) and ischemic heart disease (IHD) (OR=2.9, p<0.05), while MTHFR 1298 C allele was a risk factor for DR (OR=4.2, p<0.001) and the ACE DD genotype was a risk factor for DPN (OR=3.1, p<0.001).

CONCLUSIONS:

The MTHFR 677 TT genotype was associated with T2DM susceptibility and complications (DR, DPN and IHD). The MTHFR 1298 CC, AC and ACE DD genotypes were associated with DR and DPN.

KEYWORDS:

ACE gene; MTHFR gene; diabetic neuropathy; diabetic retinopathy; type 2 diabetes

PMID:
24452036
DOI:
10.1177/1470320313516172
[Indexed for MEDLINE]

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