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Nutrients. 2014 Jan 22;6(1):452-65. doi: 10.3390/nu6010452.

Association between lutein and zeaxanthin status and the risk of cataract: a meta-analysis.

Author information

1
The First Affiliated Hospital, Xi'an Jiaotong University College of Medicine, 277 Yanta West Road, Xi'an 710061, China. liuxiaoh@mail.xjtu.edu.cn.
2
School of Public Health, Xi'an Jiaotong University College of Medicine, 76 Yanta West Road, Xi'an 710061, China. bloodwings198927@stu.xjtu.edu.cn.
3
School of Public Health, Xi'an Jiaotong University College of Medicine, 76 Yanta West Road, Xi'an 710061, China. Liu.rong@stu.xjtu.edu.cn.
4
School of Public Health, Xi'an Jiaotong University College of Medicine, 76 Yanta West Road, Xi'an 710061, China. hzxrjm@163.com.
5
School of Public Health, Xi'an Jiaotong University College of Medicine, 76 Yanta West Road, Xi'an 710061, China. hcc.89720@stu.xjtu.edu.cn.
6
School of Public Health, Xi'an Jiaotong University College of Medicine, 76 Yanta West Road, Xi'an 710061, China. zhuhai.47344250@stu.xjtu.edu.cn.
7
School of Public Health, Xi'an Jiaotong University College of Medicine, 76 Yanta West Road, Xi'an 710061, China. male@mail.xjtu.edu.cn.

Abstract

The purpose of this meta-analysis was to evaluate the relationship between blood lutein and zeaxanthin concentration and the risk of age-related cataract (ARC). MEDLINE, EMBASE, ISI and Cochrane Library were searched to identify relevant studies up to April 2013. Meta-analysis was conducted to obtain pooled relative risks (RRs) for the highest-versus-lowest categories of blood lutein and zeaxanthin concentrations. One cohort study and seven cross-sectional studies were included in the meta-analysis. There were significant inverse associations between nuclear cataract and blood lutein and zeaxanthin concentrations, with the pooled RRs ranging from 0.63 (95% confidence interval (CI): 0.49, 0.77) for zeaxanthin to 0.73 (95% CI: 0.59, 0.87) for lutein. A stronger association between nuclear cataract and blood zeaxanthin might be noted for the studies conducted in the European Nations. Blood lutein and zeaxanthin were also noted to lead towards a decrease in the risk of cortical cataract and subcapsular cataract; however, these pooled RRs were not statistically significant, with the exception of a marginal association between lutein and subcapsular cataract. Our results suggest that high blood lutein and zeaxanthin are significantly associated with a decrease in the risk of nuclear cataract. However, no significant associations were found for ARC in other regions of the lens.

PMID:
24451312
PMCID:
PMC3916871
DOI:
10.3390/nu6010452
[Indexed for MEDLINE]
Free PMC Article

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