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Crit Care. 2014 Jan 22;18(1):404. doi: 10.1186/cc13704.

Detrimental role of humoral signalling in cardio-renal cross-talk.

Abstract

In critically ill patients, any acute organ injury is associated with a sudden change of circulating factors that may play a role in distant organ dysfunction through a complex cross-talk. In this issue, Virzì and colleagues discuss the relevance of humoral signalling between heart and kidney, focusing on type 1 and type 3 cardio-renal syndrome. We herein review the mechanisms of heart-kidney cross-talk, discussing the role of circulating detrimental mediators in the pathogenetic mechanisms of cardio-renal syndrome.

PMID:
24451176
PMCID:
PMC4056806
DOI:
10.1186/cc13704
[Indexed for MEDLINE]
Free PMC Article
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