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Biochem Soc Trans. 2014 Feb;42(1):184-7. doi: 10.1042/BST20130211.

mRNA deadenylation by Pan2-Pan3.

Author information

1
*MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, U.K.

Abstract

Poly(A) tails are important regulators of mRNA stability and translational efficiency. Cytoplasmic removal of poly(A) tails by 3'→5' exonucleases (deadenylation) is the rate-limiting step in mRNA degradation. Two exonuclease complexes contribute the majority of the deadenylation activity in eukaryotes: Ccr4-Not and Pan2-Pan3. These can be specifically recruited to mRNA to regulate mRNA stability or translational efficiency, thereby fine-tuning gene expression. In the present review, we discuss the activities and roles of the Pan2-Pan3 deadenylation complex.

PMID:
24450649
PMCID:
PMC3992365
DOI:
10.1042/BST20130211
[Indexed for MEDLINE]
Free PMC Article

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