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Circ Heart Fail. 2014 Jan;7(1):215-22. doi: 10.1161/CIRCHEARTFAILURE.113.000473.

Valvular heart disease in patients supported with left ventricular assist devices.

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School of Medicine, Division of Cardiology, and Division of Cardiothoracic Surgery, Duke University Medical Center, Durham, NC.


Patients with advanced HF and coexisting VHD who undergo LVAD implantation constitute a growing population and pose unique challenges in clinical and surgical management. Contemporary continuous-flow LVADs alter blood flow dynamics and cardiovascular physiology and can induce progression of preexisting VHD or lead to de novo VHD. Although we have defined our recommendations for treatment options (Table 2), continued changes to device technology, patient selection, and surgical techniques will undoubtedly lead to further changes in practice. Finally, the rapid growth in the field of mechanical circulatory support necessitates collaborative multicenter approaches to study the impact of these practice changes in the form of prospective randomized trials.


advanced heart failure; mechanical circulatory support; valvular heart disease

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