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Chem Commun (Camb). 2014 Mar 4;50(18):2350-2. doi: 10.1039/c3cc49486a. Epub 2014 Jan 21.

Direct access to isoindolines through tandem Rh(III)-catalyzed alkenylation and cyclization of N-benzyltriflamides.

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  • 1School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea. insukim@skku.edu.

Abstract

The rhodium-catalyzed oxidative alkenylation of N-benzyltriflamides with olefins followed by an intramolecular cyclization via C-H bond activation is described. This method results in the direct and efficient synthesis of highly substituted isoindoline frameworks.

PMID:
24448389
DOI:
10.1039/c3cc49486a
[PubMed - indexed for MEDLINE]
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