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Molecules. 2014 Jan 20;19(1):1250-7. doi: 10.3390/molecules19011250.

Two new secondary metabolites from Xylaria sp. cfcc 87468.

Author information

1
Department of Pharmacy, Wuhan First Hospital, Wuhan 430022, Hubei, China. wangfuqian.c@163.com.
2
Department of Pharmacy, Wuhan First Hospital, Wuhan 430022, Hubei, China. mshss880910@163.com.
3
Department of Pharmacy, Wuhan First Hospital, Wuhan 430022, Hubei, China. huyaoshi@sina.com.cn.
4
Department of Pharmacy, Wuhan First Hospital, Wuhan 430022, Hubei, China. yongboxue@mail.hust.edu.cn.
5
Department of Pharmacy, Wuhan First Hospital, Wuhan 430022, Hubei, China. jpwang1001@163.com.
6
Department of Pharmacy, Wuhan First Hospital, Wuhan 430022, Hubei, China. xhf991030@tom.com.
7
Department of Pharmacy, Wuhan First Hospital, Wuhan 430022, Hubei, China. chenglu19810620@163.com.
8
Department of Pharmacy, Wuhan First Hospital, Wuhan 430022, Hubei, China. zhanggen888@126.com.
9
Department of Pharmacy, Wuhan First Hospital, Wuhan 430022, Hubei, China. zhangyh@mails.tjmu.edu.cn.

Abstract

A new isocoumarin glycoside, 3R-(+)-5-O-[6'-O-acetyl]-α-D-glucopyranosyl-5-hydroxymellein (1), and a new phenylethanol glycoside, (-)-phenylethyl-8-O-α-L-rhamno-pyranoside (2), were isolated from the ethyl acetate extract of the fungus Xylaria sp. cfcc 87468, together with five known steroids, β-sitosterol (3), stigmast-4-en-3-one (4), ergosterol (5), (22E)-cholesta-4,6,8(14),22-tetraen-3-one (6), and 4α-methyl- ergosta-8(14),24(28)-dien-3β-ol (7). The structures of compounds 1 and 2 were elucidated by MS, extensive 1D and 2D NMR spectroscopy, and the circular dichroism (CD) spectroscopy.

PMID:
24448065
PMCID:
PMC6270958
DOI:
10.3390/molecules19011250
[Indexed for MEDLINE]
Free PMC Article

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