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Daru. 2014 Jan 21;22(1):19. doi: 10.1186/2008-2231-22-19.

The hypoglycemic effect of Juglans regia leaves aqueous extract in diabetic patients: A first human trial.

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1
Department of Nutrition, Tehran University of Medical Sciences, School of Public Health, Tehran, Iran. jamshidi.nutrition@yahoo.com.

Abstract

BACKGROUND:

Juglans regia L. (J. regia ) is one of the medicinal plants traditionally used for treatment of diabetes in Iranian medicine. The effect of this plant has already been investigated on animal models; however, this is the first study conducted on human subjects. The aim of this study is to investigate the hypoglycemic effect of J. regia leaves aqueous extract in type 2 diabetes patients. Fifty eight Iranian male and female patients with type 2 diabetes were enrolled. The patients were randomly allocated into two groups. One group (nā€‰=ā€‰30) received J. regia leaves extract while the other group (nā€‰=ā€‰28) received placebo. Fasting blood samples were collected at the beginning of the study and after two months for determination of HbA1c and blood glucose level as a main outcome and insulin, SGOT, SGPT, and ALP level as secondary outcome.

RESULTS:

Our analysis showed that serum fasting HbA1C and blood glucose levels were significantly decreased and the insulin level was increased in patients in the J. regia arm.

CONCLUSIONS:

The results indicate that J. regia aqueous extract favorably affects blood levels of glucose, insulin and HbA1C in type 2 diabetic patients.

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