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Acta Oncol. 2014 Jul;53(7):952-7. doi: 10.3109/0284186X.2013.879608. Epub 2014 Jan 21.

Human papilloma virus detection and typing in 334 lung cancer patients.

Author information

1
Department of Oncology, Oslo University Hospital, The Norwegian Radium Hospital , Oslo , Norway.

Abstract

BACKGROUND:

Unlike cervical, anogenital and oropharyngeal cancers, where high-risk human papillomavirus (hrHPV) has long been known to play a major role, a causative link between HPV and lung cancer has been investigated for decades with discrepant results.

METHODS:

Lung cancer patients eligible for surgical treatment were tested for the presence of HPV-DNA in excised, fresh frozen lung tumor tissue. Patients that tested positive were further examined for the presence of HPV-DNA in adjacent normal lung parenchyma. HPV detection and genotyping was performed using a polymerase chain reaction (PCR)-based approach and allowed the typing of 13 "high-risk"-HPV-types and 2 "low-risk"-HPV-types.

RESULTS:

Of the 334 tumor-DNA samples tested, 13 (3.9%) showed presence of HPV-DNA, of which 12 were of a high-risk HPV type (16, 33, 66). In those tested positive, HPV-DNA was not found in adjacent normal lung tissue. No correlation with smoking or EGFR/KRAS mutation status was seen, and only one of 84 squamous cell carcinomas was HPV-positive.

CONCLUSION:

We conclude that HPV is rarely associated with lung cancer in a Northern European population and in those tested positive, more functional studies are required to determine the role HPV plays in lung cancer oncogenesis.

PMID:
24446743
DOI:
10.3109/0284186X.2013.879608
[Indexed for MEDLINE]

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