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Biomarkers. 2014 Mar;19(2):109-13. doi: 10.3109/1354750X.2013.877967. Epub 2014 Jan 22.

Presence of cytomegalovirus DNA in leucocytes is associated with increased oxidative stress and subclinical atherosclerosis in healthy adults.

Author information

1
Department of Internal Medicine, Division of Infectious Diseases, Changhua Christian Hospital , Changhua , Taiwan .

Abstract

OBJECTIVE:

Investigate the latent cytomegalovirus (CMV) infection as a biomarker of oxidative stress and atherosclerosis.

METHODS:

Latent CMV infection was diagnosed in healthy individuals with PCR-evidence of CMV DNA in peripheral leucocytes. Oxidative stress and atherosclerosis were measured by mitochondrial DNA oxidative damage index (mtDNA(ΔCT)) and intima media thickness (IMT).

RESULTS:

The CMV DNA positive subjects had a higher mean mtDNA(ΔCT) and greater IMT than subjects in the control group.

CONCLUSIONS:

Presence of CMV DNA in leucocytes, as a marker of latent CMV infection, was associated with increased levels of oxidative stress and subclinical atherosclerosis in healthy adults.

PMID:
24446591
DOI:
10.3109/1354750X.2013.877967
[Indexed for MEDLINE]

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