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Philos Trans R Soc Lond B Biol Sci. 2014 Jan 20;369(1637):20120467. doi: 10.1098/rstb.2012.0467. Print 2014 Mar 5.

Reading spike timing without a clock: intrinsic decoding of spike trains.

Author information

1
Institute of Neuroscience and Psychology, University of Glasgow, , Glasgow G12 8QB, UK.

Abstract

The precise timing of action potentials of sensory neurons relative to the time of stimulus presentation carries substantial sensory information that is lost or degraded when these responses are summed over longer time windows. However, it is unclear whether and how downstream networks can access information in precise time-varying neural responses. Here, we review approaches to test the hypothesis that the activity of neural populations provides the temporal reference frames needed to decode temporal spike patterns. These approaches are based on comparing the single-trial stimulus discriminability obtained from neural codes defined with respect to network-intrinsic reference frames to the discriminability obtained from codes defined relative to the experimenter's computer clock. Application of this formalism to auditory, visual and somatosensory data shows that information carried by millisecond-scale spike times can be decoded robustly even with little or no independent external knowledge of stimulus time. In cortex, key components of such intrinsic temporal reference frames include dedicated neural populations that signal stimulus onset with reliable and precise latencies, and low-frequency oscillations that can serve as reference for partitioning extended neuronal responses into informative spike patterns.

KEYWORDS:

decoding; information theory; neural code; oscillations; sensation; spike patterns

PMID:
24446501
PMCID:
PMC3895992
DOI:
10.1098/rstb.2012.0467
[Indexed for MEDLINE]
Free PMC Article
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