Format

Send to

Choose Destination
See comment in PubMed Commons below
Anesth Analg. 2014 Feb;118(2):346-57. doi: 10.1213/ANE.0000000000000050.

Low-dose hydrocortisone therapy attenuates septic shock in adult patients but does not reduce 28-day mortality: a meta-analysis of randomized controlled trials.

Author information

1
From the *Department of Anesthesiology, The First Affiliated Hospital of Harbin Medical University; †Department of Medical Records, the First Hospital of Quanzhou, Quanzhou, China; ‡Department of Microbiology, The Heilongjiang Key Laboratory of Immunity and Infection, Pathogenic Biology, Harbin Medical University; and §Key Laboratory of Bio-Pharmaceutical, Harbin Medical University, Ministry of Education, Harbin, China.Jiaxiao Sun, MSc, is currently affiliated with Department of Anesthesiology, the First Hospital of Quanzhou, Quanzhou, China. Juanjuan Zheng, is currently affiliated with Department of Medical Records, the First Hospital of Quanzhou, Quanzhou, China.

Abstract

BACKGROUND:

The role of low-dose hydrocortisone in attenuating septic shock and reducing short-term mortality in adult patients with septic shock is unclear. We conducted a meta-analysis of previous studies to determine whether hydrocortisone could ameliorate the effects of septic shock at 7 and 28 days and reduce 28-day morality.

METHODS:

Randomized controlled trials (RCTs) of corticosteroids versus placebo (or supportive treatment alone) were retrieved from electronic searches (Medline, Embase, and Cochrane Library databases; LILACS; and Web of Knowledge) and manual searches (up to May 2012). From a pool of 1949 potentially relevant articles, duplicate independent review identified 10 relevant, RCTs of low-dose hydrocortisone therapy in septic shock. Four pairs of reviewers agreed on the criteria for trial eligibility. One reviewer entered the data into the computer, and 3 reviewers checked the data. Missing data were obtained from the authors of the relevant trials. The primary outcome analyzed was an estimate of 28-day mortality.

RESULTS:

Eight publications were included in the meta-analysis. Low-dose hydrocortisone therapy did not reduce 28-day mortality (N = 1063; odds ratio (OR) = 0.891, 95% confidence interval (CI), 0.69-1.15). Low-dose hydrocortisone therapy ameliorated shock at 7 days (6 RCTs, N = 964, OR = 2.078, 95% CI, 1.58-2.73, P < 0.0001, and I = 26.9%) and 28 days (6 RCTs, N = 947, OR = 1.495, 95% CI, 1.12-1.99, P = 0.006, and I = 0.0%).

CONCLUSIONS:

Although low-dose hydrocortisone therapy ameliorates septic shock at 7 and 28 days, it does not reduce 28-day mortality.

PMID:
24445635
DOI:
10.1213/ANE.0000000000000050
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for Wolters Kluwer
    Loading ...
    Support Center