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AIDS. 2014 Mar 13;28(5):793-5. doi: 10.1097/QAD.0000000000000201.

Specific loss of cellular L-selectin on CD4(+) T cells is associated with progressive multifocal leukoencephalopathy development during HIV infection.

Author information

1
Department of Neurology, University of Münster, Münster, Germany.

Abstract

HIV(+) progressive multifocal leukoencephalopathy (PML) patients had a significantly lower expression of CD62L on CD4(+) T cells (P < 0.001) when compared with HIV(+) patients who did not develop PML. CD62L expression on CD4(+) T cells did not correlate with parameters such as CDC stage, CD4(+) cell percentage (of total CD3(+) T cells), CD4(+) cell counts, virus count, or clinical parameters. Measurement of CD62L might provide a biomarker for PML risk and could prompt a treatment change and/or close monitoring.

PMID:
24445368
DOI:
10.1097/QAD.0000000000000201
[Indexed for MEDLINE]

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