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Heart Rhythm. 2014 Apr;11(4):663-9. doi: 10.1016/j.hrthm.2014.01.018. Epub 2014 Jan 18.

Relations between circulating microRNAs and atrial fibrillation: data from the Framingham Offspring Study.

Author information

1
National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts; Cardiology Division, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts; Epidemiology Division, Department of Quantitative Health Sciences, University of Massachusetts Medical School Worcester, Massachusetts. Electronic address: mcmanusd@ummhc.org.
2
National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts; Computational Biomedicine Section, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts.
3
National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts; Cardiology Division, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts.
4
Cardiology Division, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts.
5
National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts.
6
National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts; Department of Mathematics and Statistics, Boston University, Boston, Massachusetts; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts.
7
Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, Massachusetts; Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts.
8
National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts; Population Research Branch and Division of Intramural Research, National Heart, Lung, and Blood Institute of the National Institutes of Health, Bethesda, Massachusetts.
9
Section of Cardiovascular Medicine, Department of Medicine, Boston University, Boston, Massachusetts; Preventive Medicine Section, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts; Epidemiology Department, Boston University School of Public Health, Boston, Massachusetts.

Abstract

BACKGROUND:

MicroRNA (miRNA) expression in atrial tissue has been implicated in pathologic susceptibility to atrial fibrillation (AF). Nevertheless, data on how circulating levels relate to AF are limited.

OBJECTIVE:

The purpose of this study was to test the hypothesis that circulating miRNAs are associated with AF.

METHODS:

Among 2445 Framingham Heart Study Offspring participants, we measured the expression of 385 circulating whole blood miRNAs by high-throughput quantitative reverse transcriptase polymerase chain reaction. We related miRNA levels with prevalent and new-onset AF.

RESULTS:

Mean age of the cohort was 66.3 ± 8.9 years, and 56% were women; 153 participants had clinically apparent AF at baseline, and 107 developed AF during median follow-up of 5.4 years. miRNA-328 (miR-328) expression was lower among participants with prevalent AF (8.76 cycle threshold) compared to individuals with no AF (7.75 cycle threshold, P <.001). The association between miR-328 and prevalent AF persisted after adjustment for age, sex, and technical covariates (odds ratio 1.21, P = 1.8 × 10(-4)) but was attenuated in analyses adjusting for clinical AF risk factors (odds ratio 1.14, P = .017). In contrast to the associations between miR-328 and prevalent AF, none of the circulating miRNAs were associated with incident AF.

CONCLUSION:

Circulating levels of miR-328, a miRNA known to promote atrial electrical remodeling by reducing L-type Ca(2+) channel density, were associated with prevalent AF. Adjustment for risk factors that promote atrial remodeling, including hypertension, attenuated the association between miR-328 and AF, potentially implicating miR-328 as a potential mediator of atrial remodeling and AF vulnerability.

KEYWORDS:

Atrial fibrillation; Circulation; Epidemiology; Risk factors; microRNA

PMID:
24444445
PMCID:
PMC4219255
DOI:
10.1016/j.hrthm.2014.01.018
[Indexed for MEDLINE]
Free PMC Article

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