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Phytochem Lett. 2014 Feb 1;7:42-45.

Compounds from Simarouba berteroana which inhibit proliferation of NF1-defective cancer cells.

Author information

1
Molecular Targets Laboratory, Center for Cancer Research, Frederick, Maryland 21702, United States.
2
Molecular Targets Laboratory, Center for Cancer Research, Frederick, Maryland 21702, United States ; SAIC-Frederick, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, United States.
3
Mouse Cancer Genetics Program, Center for Cancer Research, Frederick, Maryland 21702, United States.

Abstract

A neurofibromatosis type 1 (NF1) based bioassay-guided phytochemical investigation on Simarouba berteroana led to the isolation of one new canthin-6-one-9-methoxy-5-O-β-D-glucopyranoside (1), seven known canthine alkaloids (2-8), two known quassinoids (9-10) and a known neo-lignan (11). The structures of all compounds were established by HRMS, 1D- and 2D-NMR analysis and comparison with previously reported data. Most of the compounds inhibited the proliferation of an Nf1- and p53-deficient mouse glioma cell line at non-cytotoxic concentrations.

KEYWORDS:

Neurofibromatosis type 1; Simarouba berteroana; canthine alkaloids; glioblastomas; growth inhibition

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