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Bone Marrow Transplant. 2014 May;49(5):607-10. doi: 10.1038/bmt.2013.216. Epub 2014 Jan 20.

Conditioning regimens in allo-SCT for thalassemia major.

Author information

1
Department of Hematology, Christian Medical College, Vellore, India.
2
Hematology and Stem Cell Transplantation Section, Division of Hematology/Oncology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center and Veterans Affairs Medical Center, Nashville, TN, USA.

Abstract

Allogeneic hematopoietic SCT remains the only treatment that can correct the hematological manifestations in patients with thalassemia major. Improving the clinical outcomes of high-risk, heavily transfused patients with liver fibrosis and inadequate iron chelation remains a challenge. Because of the relatively high probability of graft rejection and regimen-related toxicity in many patients receiving SCT for advanced thalassemia major, further development of new treatment regimens is warranted. This review addresses the reported clinical studies in patients with advanced thalassemia major and we have summarized our suggested conditioning approach to improve the outcome after SCT.

PMID:
24442250
DOI:
10.1038/bmt.2013.216
[Indexed for MEDLINE]
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