Abstract
Chemical investigation of a Formosan sponge Axinyssa sp. has led to the isolation of five nitrogenous bisabolene-type sesquiterpenes 1-5, including two new compounds axinysalines A (1) and B (2). The structures of new compounds were elucidated by analysis of high resolution (HR)-MS and two dimensional (2D)-NMR spectra and comparison of its NMR data with those of known analogues. Compound 1 exhibited moderate to weak cytotoxicity against Molt 4 and K562 cancer cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology
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Cell Line, Tumor / drug effects
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Drug Screening Assays, Antitumor
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Humans
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K562 Cells / drug effects
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Porifera / chemistry*
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Sesquiterpenes / chemistry*
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / pharmacology
Substances
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Antineoplastic Agents
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Sesquiterpenes
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axinysaline A
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axinysaline B