New nitrogenous bisabolene-type sesquiterpenes from a formosan sponge Axinyssa sp

Chem Pharm Bull (Tokyo). 2014;62(4):392-4. doi: 10.1248/cpb.c13-00851. Epub 2014 Jan 17.

Abstract

Chemical investigation of a Formosan sponge Axinyssa sp. has led to the isolation of five nitrogenous bisabolene-type sesquiterpenes 1-5, including two new compounds axinysalines A (1) and B (2). The structures of new compounds were elucidated by analysis of high resolution (HR)-MS and two dimensional (2D)-NMR spectra and comparison of its NMR data with those of known analogues. Compound 1 exhibited moderate to weak cytotoxicity against Molt 4 and K562 cancer cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology
  • Cell Line, Tumor / drug effects
  • Drug Screening Assays, Antitumor
  • Humans
  • K562 Cells / drug effects
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Porifera / chemistry*
  • Sesquiterpenes / chemistry*
  • Sesquiterpenes / isolation & purification
  • Sesquiterpenes / pharmacology

Substances

  • Antineoplastic Agents
  • Sesquiterpenes
  • axinysaline A
  • axinysaline B