Format

Send to

Choose Destination
QJM. 2014 Oct;107(10):789-92. doi: 10.1093/qjmed/hcu005. Epub 2014 Jan 18.

A novel regulator of lung inflammation and immunity: pulmonary parasympathetic inflammatory reflex.

Author information

1
From the Unit of Respiratory Infection and Immunity, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.
2
From the Unit of Respiratory Infection and Immunity, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China xsu@ips.ac.cn.

Abstract

In this review, we first analyzed the current status of cholinergic anti-inflammatory pathway and then put forward a novel regulatory machinery-pulmonary parasympathetic inflammatory reflex, which is composed by lung vagal sensors at afferent arm, α7 nAChR (α7 nicotinic acetylcholine receptors)-expressing cells at efferent arm and the brain information integrating center. This modulatory circuit might loop the lungs, immune and nervous systems and play a very important role in regulating lung infection, inflammation and immunity through the neural innervations and signals when the lungs encounter pathogenic challenges.

PMID:
24440925
DOI:
10.1093/qjmed/hcu005
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center