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Pharmacol Biochem Behav. 2014 Jun;121:184-8. doi: 10.1016/j.pbb.2014.01.004. Epub 2014 Jan 15.

The 5-HT₁A receptor C(1019)G polymorphism influences the intravaginal ejaculation latency time in Dutch Caucasian men with lifelong premature ejaculation.

Author information

1
Division Pharmacology, Utrecht Institute for Pharmaceutical Sciences and Rudolf Magnus Institute for Neurosciences, Utrecht University, Utrecht, The Netherlands; Department of Central Hospital Pharmacy, Viecuri Hospital Venlo, Venlo, The Netherlands.
2
Department of Clinical Chemistry (AKC), Erasmus University Medical Center (Erasmus MC), Rotterdam, The Netherlands.
3
Department of Medical Statistics, Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
4
Division Pharmacology, Utrecht Institute for Pharmaceutical Sciences and Rudolf Magnus Institute for Neurosciences, Utrecht University, Utrecht, The Netherlands; Yale University School of Medicine, New Haven, CT, USA.
5
Division Pharmacology, Utrecht Institute for Pharmaceutical Sciences and Rudolf Magnus Institute for Neurosciences, Utrecht University, Utrecht, The Netherlands; Outpatient Department of Neurosexology, HagaZiekenhuis, The Hague, The Netherlands. Electronic address: md@waldinger.demon.nl.

Abstract

INTRODUCTION:

Lifelong premature ejaculation (LPE) is characterized by persistent intravaginal ejaculation latency times (IELTs) of less than 1 min, and has been postulated as a neurobiological dysfunction related to diminished serotonergic neurotransmission with 5-HT₁A receptor hyperfunction and 5-HT₂C hypofunction.

AIM:

To investigate the relationship between 5-HT₁A receptor gene (HTR₁A)-C(1019)G promoter polymorphism and IELT in men with LPE. This polymorphism is known to increase 5-HT1A receptor expression.

METHODS:

A prospective study was conducted in 54 Dutch Caucasian men with LPE. Baseline IELT during coitus was assessed by stopwatch over a 1-month period. All men were genotyped for HTR₁A gene polymorphism. Allele frequencies and genotypes of C and G variants of HTR₁A polymorphism were determined. Association between CC, CG, and GG genotypes and the IELT in men with LPE were investigated.

MAIN OUTCOME MEASURES:

IELT measured by stopwatch, HTR₁A polymorphism.

RESULTS:

In this cohort of men with LPE, the geometric mean IELT was 23.8 s. Of the 54 men, the CC, CG and GG genotype frequency for the C(1019)G polymorphism of the 5-HT₁A gene was 33%, 43% and 24%, respectively. The geometric mean IELT for the CC, CG and GG genotypes were 14.5, 27.7 and 36.0 s, respectively (p=0.019). Compared to GG and CG genotypes, men with CC genotype had a 250% and 190% shorter ejaculation time, respectively.

CONCLUSIONS:

HTR₁A gene polymorphism is associated with the IELT in men with LPE. Men with CC genotype have shorter IELTs than men with GG and CG genotypes.

KEYWORDS:

5-HT(1A) receptor gene C(−1019)G polymorphism; Genetics; Genotype; IELT; Lifelong premature ejaculation

PMID:
24440118
DOI:
10.1016/j.pbb.2014.01.004
[Indexed for MEDLINE]

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