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Nutr Metab Cardiovasc Dis. 2014 Feb;24(2):176-82. doi: 10.1016/j.numecd.2013.07.003. Epub 2014 Jan 17.

Metabolic syndrome and long-term cardiovascular outcomes in NSTEMI with unstable angina.

Author information

1
Department of Cardiology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey. Electronic address: doktorseref@hotmail.com.
2
Department of Cardiology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.
3
Department of Cardiology, Mehmet Akif Ersoy Thoracic-Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.
4
Department of Emergency, Faculty Of Medicine, Bezmialem Vakif University, Istanbul, Turkey.
5
Department of Cardiology, Siyami Ersek Thoracic-Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.

Abstract

BACKGROUND AND AIM:

Metabolic syndrome (MS) is associated with cardiovascular mortality and morbidity in patients with acute coronary syndrome. The purpose of this study was to evaluate the impact of MS on long-term clinical outcomes in patients with pure non-ST segment myocardial infarction (NSTEMI) or unstable angina pectoris (USAP).

METHODS AND RESULTS:

We prospectively enrolled 310 consecutive NSTEMI/USAP patients (74 females; mean age, 59.3 ± 11.9 years). The study population was divided into two groups: MS(+) and MS(-). The clinical outcomes of the patients were followed for up to 3 years. Increased 3-year cardiovascular mortality and reinfarction were observed in the MS(+) group, as compared to the MS(-) group (15 vs. 3.4%, p = 0.001, and 22.2 vs. 8.3%, p = 0.001, respectively). Hospitalization rates for heart failure and stroke were not significantly different between the two groups on follow-up. By a Cox multivariate analysis, a significant association was noted between MS and the adjusted risk of 3-year cardiovascular mortality (odds ratio 3.4, 95% confidence interval, 1.24-9.1, p = 0.02).

CONCLUSION:

These results suggest that MS is associated with an increased risk of 3-year cardiovascular mortality and reinfarction in patients with NSTEMI/USAP.

KEYWORDS:

Acute coronary syndrome; Cardiovascular mortality; Metabolic syndrome; Reinfarction

PMID:
24439842
DOI:
10.1016/j.numecd.2013.07.003
[Indexed for MEDLINE]

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