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Curr Top Dev Biol. 2014;107:161-81. doi: 10.1016/B978-0-12-416022-4.00006-8.

Satellite cells: the architects of skeletal muscle.

Author information

1
The Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
2
The Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada. Electronic address: mrudnicki@ohri.ca.

Abstract

The outstanding regenerative capacity of skeletal muscle is attributed to the resident muscle stem cell termed satellite cell. Satellite cells are essential for skeletal muscle regeneration as they ultimately provide the myogenic precursors that rebuild damaged muscle tissue. Satellite cells characteristically are a heterogeneous population of stem cells and committed progenitor cells. Delineation of cellular hierarchy and understanding how lineage fate choices are determined within the satellite cell population will be invaluable for the advancement of muscle regenerative therapies.

KEYWORDS:

Development; Muscle stem cells; Myogenesis; Pax3; Pax7; Regeneration; Satellite cells; Skeletal muscle; Therapy

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