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J Pediatr Surg. 2014 Jan;49(1):144-7; discussion 147-8. doi: 10.1016/j.jpedsurg.2013.09.068. Epub 2013 Nov 22.

Predictors of ovarian malignancy in children: overcoming clinical barriers of ovarian preservation.

Author information

1
Division of Pediatric Surgery, Department of Surgery, Indiana University School of Medicine, Riley Hospital for Children, Indianapolis, IN, USA.
2
Division of Pediatric Surgery, Department of Surgery, Indiana University School of Medicine, Riley Hospital for Children, Indianapolis, IN, USA; Children's Health Services Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
3
Department of Biostatistics, Indiana University, Indianapolis, IN, USA.
4
Division of Pediatric Surgery, Department of Surgery, Indiana University School of Medicine, Riley Hospital for Children, Indianapolis, IN, USA. Electronic address: frescorl@iupui.edu.

Abstract

BACKGROUND/PURPOSE:

Ovarian preservation is desirable in girls with benign ovarian masses. We aimed to 1) identify clinical predictors of malignant ovarian masses, 2) investigate how often ovarian tissue is present to preserve in benign masses, and 3) identify factors associated with successful ovarian preservation.

METHODS:

Retrospective analysis (1997-2012) of girls age 1-18years with an ovarian mass managed operatively. Data on presenting symptoms, imaging, biochemical markers, treatment, outcome, and pathology were extracted.

RESULTS:

We identified 150 patients. Large mass size, solid components, and elevated tumor markers (AFP, βHCG, and/or LDH) were significantly predictive of malignancy. All masses <10cm, predominantly cystic, and with negative tumor markers were benign. Masses with all three of these characteristics would decrease a 20% malignancy pretest probability to a posttest probability of 0.25%. Benign masses managed by oophorectomy contained normal ovarian tissue in 76% of the specimens. For benign masses, successful ovarian preservation was significantly associated with size <10cm, predominantly cystic, laparoscopy, and absence of torsion or calcifications.

CONCLUSION:

Ovarian masses that are <10cm, primarily cystic, and have negative tumor markers are most likely benign. Viable ovarian tissue is frequently present in benign masses, so significant efforts should be made for ovarian preservation.

KEYWORDS:

Children; Fertility sparing; Ovarian malignancy; Ovarian mass; Ovarian preservation

PMID:
24439599
DOI:
10.1016/j.jpedsurg.2013.09.068
[Indexed for MEDLINE]

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