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Diabetes Metab. 2014 Apr;40(2):158-60. doi: 10.1016/j.diabet.2013.12.006. Epub 2014 Jan 14.

Acute caloric restriction improves glomerular filtration rate in patients with morbid obesity and type 2 diabetes.

Author information

1
Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; Unit of Endocrinology, Diabetes and Metabolism, S. Giovanni Calibita Fatebenefratelli Hospital, Lungotevere de' Cenci 7, 00186 Rome, Italy.
2
Service of Medical Statistics & Information Technology, Fatebenefratelli Association for Research (SeSMIT-AFaR), S. Giovanni Calibita Fatebenefratelli Hospital, Lungotevere de' Cenci 5, 00186 Rome, Italy; AFaR, Unit of Internal Medicine, S. Giovanni Calibita Fatebenefratelli Hospital, Lungotevere de' Cenci 5, 00186 Rome, Italy.
3
Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; Unit of Endocrinology, Diabetes and Metabolism, S. Giovanni Calibita Fatebenefratelli Hospital, Lungotevere de' Cenci 7, 00186 Rome, Italy. Electronic address: frontoni@uniroma2.it.

Abstract

AIM:

The role of caloric restriction in the improvement of renal function following bariatric surgery is still unclear; with some evidence showing that calorie restriction can reduce proteinuria. However, data on the impact of caloric restriction on renal function are still lacking.

METHODS:

Renal function, as measured by glomerular filtration rate (GFR), was evaluated in 14 patients with type 2 diabetes mellitus, morbid obesity and stage 2 chronic kidney disease before and after a 7-day very low-calory diet (VLCD).

RESULTS:

After the VLCD, both GFR and overall glucose disposal (M value) significantly increased from 72.6 ± 3.8 mL/min/1.73 m(-2) BSA to 86.9 ± 6.1 mL/min/1.73 m(-2) BSA (P=0.026) and from 979 ± 107 μmol/min(1)/m(2) BSA to 1205 ± 94 μmol/min(1)/m(2) BSA (P=0.008), respectively. A significant correlation was observed between the increase in GFR and the rise in M value (r=0.625, P=0.017).

CONCLUSION:

Our observation of improved renal function following acute caloric restriction before weight loss became relevant suggesting that calory restriction per se is able to affect renal function.

KEYWORDS:

Caloric restriction; Diabetes mellitus; Glomerular filtration rate; Morbid obesity

PMID:
24439268
DOI:
10.1016/j.diabet.2013.12.006
[Indexed for MEDLINE]

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