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Cytotherapy. 2014 Feb;16(2):278-84. doi: 10.1016/j.jcyt.2013.11.001.

Treatment of multiple solitary plasmacytomas with cytokine-induced killer cells.

Author information

1
Department of Geriatric Hematology, Chinese PLA General Hospital, Beijing, China.
2
Department of Cadre Health Care, Chinese PLA Navy General Hospital, Beijing, China.
3
Department of Geriatric Laboratory Medicine, Chinese PLA General Hospital, Beijing, China.
4
Institute of Otorhinolaryngology, Chinese PLA General Hospital, Beijing, China.
5
Department of Pharmacy, the Second Artillery General Hospital, Beijing, China.
6
Department of Geriatric Hematology, Chinese PLA General Hospital, Beijing, China. Electronic address: luxuechun@126.com.

Abstract

BACKGROUND AIMS:

Currently available treatment methods for advanced plasmacytoma include surgery, chemotherapy, radiotherapy, immunomodulatory agents, hematopoietic stem cell transplantation and donor lymphocyte infusion. We report a case of advanced refractory multiple solitary plasmacytomas in a 68-year-old Asian man with multiple bone lesions, in whom autologous cytokine-induced killer (CIK) cells were administered in an effort to eliminate residual tumor lesions.

METHODS:

CIK cells were infused monthly for 21 courses.

RESULTS:

The patient has survived 63 months since the first hospital visit without disease progression for 40 months.

CONCLUSIONS:

This case represents the first report of autologous CIK cell immunotherapy used successfully to suppress multiple solitary plasmacytomas and resolve bone lesions.

KEYWORDS:

cancer; chemotherapy; cytokine-induced killer cells; immunotherapy; plasmacytoma

PMID:
24438905
DOI:
10.1016/j.jcyt.2013.11.001
[Indexed for MEDLINE]

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