Format

Send to

Choose Destination
Nature. 1987 Oct 8-14;329(6139):512-8.

The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens.

Author information

1
Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts.

Abstract

Most of the polymorphic amino acids of the class I histocompatibility antigen, HLA-A2, are clustered on top of the molecule in a large groove identified as the recognition site for processed foreign antigens. Many residues critical for T-cell recognition of HLA are located in this site, in positions allowing them to serve as ligands to processed antigens. These findings have implications for how the products of the major histocompatibility complex (MHC) recognize foreign antigens.

PMID:
2443855
DOI:
10.1038/329512a0
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center