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Chem Sci. 2014 Jan 1;5(1):151-155.

Highly Potent, Chemically Stable Quorum Sensing Agonists for Vibrio Cholerae.

Author information

1
Department of Chemistry, Princeton University, Washington Road, Princeton, NJ 08544 (USA).
2
Department of Molecular Biology, Princeton University, Washington Road, Princeton, NJ 08544 (USA).
3
Department of Molecular Biology, Princeton University, Washington Road, Princeton, NJ 08544 (USA) ; Howard Hughes Medical Institute Chevy Chase, MD 02815.

Abstract

In the Vibrio cholerae pathogen, initiation of bacterial quorum sensing pathways serves to suppress virulence. We describe herein a potent and chemically stable small molecule agonist of V. cholerae quorum sensing, which was identified through rational drug design based on the native quorum sensing signal. This novel agonist may serve as a useful lead compound for the control of virulence in V. cholerae.

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